Synthetic RNA constructs using non-canonical base pairing show promising advancements in nanostructure design, indicating new applications.
Synthetic RNA nanostructures are typically composed of four nucleotides (A, U, G, and C) following a canonical base pairing rule (A-U/G-C). Non-canonical A·C base paring is applied in the RNA constructs with three-letter coding (A, G and C).
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Zhao et al. (2026) studied this question.
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