Rapid Relief of Nasopharyngeal and Posterior Pharyngeal Inflammatory Symptoms After Nasopharyngeal Administration of High-Concentration 35 kDa Hyaluronan: A Case Series

Background: Chronic rhinitis and chronic pharyngitis are common upper airway inflammatory conditions that significantly impair quality of life. Effective non-pharmacological interventions for rapid symptom relief remain limited. Objective: To evaluate the symptom-relieving effects of nasopharyngeal administration of high-concentration 35 kDa hyaluronic acid fragments (HA35) in individuals with chronic nasopharyngeal and posterior pharyngeal inflammatory discomfort, and to assess changes in subjective mental clarity. Methods: This case series included seven volunteers with concomitant chronic rhinitis and chronic pharyngitis. Participants received a 13.6% high-concentration HA35 nasopharyngeal care gel twice daily for 10 consecutive days. A standardized 0–10 numerical rating scale (NRS) was used to assess nasopharyngeal discomfort, posterior pharyngeal discomfort, nasal airflow, overall inflammatory symptom severity, and subjective mental clarity at predefined time points. Results: Within 30 minutes of the first administration, nasopharyngeal discomfort, posterior pharyngeal discomfort, sneezing, cough, and nasal obstruction scores decreased markedly in all participants. After 10 days of continuous treatment, symptoms of chronic rhinitis and pharyngitis were substantially alleviated, with most scores reduced to mild levels or near resolution. All participants reported a notable improvement in subjective mental clarity within 1–3 hours following the first morning administration. Three participants experienced transient difficulty initiating sleep when the product was administered shortly before bedtime. Conclusion: In this case series, nasopharyngeal administration of high-concentration HA35 was associated with rapid relief of upper airway inflammatory discomfort and improved subjective mental clarity.