Precise control over chemical reactivity remains a central challenge in synthetic chemistry, where reactions are typically governed by random molecular encounters in homogeneous solutions. By contrast, biological systems achieve exceptional efficiency and selectivity under dilute conditions by relying on self‐organization: folded biomacromolecules and dynamic assemblies confine reactive groups, modulate local environments, and enhance effective molarity. Inspired by these strategies, supramolecular self‐assembly has emerged as a powerful platform for regulating chemical transformations through spatial and temporal organization. Ordered microstructures and nanostructures formed through noncovalent interactions can bring reactive species into close proximity, orient them productively, and introduce cooperative or catalytic effects. Recent advances extend beyond static architectures toward dynamic and out‐of‐equilibrium assemblies capable of adapting their structure and function in response to stimuli or chemical fuels. This Perspective highlights emerging approaches that integrate chemical reactivity with dynamic supramolecular organization, emphasizing mechanisms of reaction acceleration—including increased effective molarity, emergent catalysis, and microenvironment modulation—and outlining design principles for constructing adaptive systems that emulate nature's precision in controlling chemical processes.
Cui et al. (Sun,) studied this question.