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February 5, 2026Microbial Genomics0 citationsOpen Access

Genomic Features of Pneumococcal Strains in Pediatric Patients Post-Vaccine Introduction

Genomic features of pneumococcal strains isolated from paediatric patients with invasive disease during pneumococcal conjugate vaccine introduction in Lima, Peru

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Authors

BGBrayan E. GonzalesDDDavid DurandEMErik H. Mercado

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Overview

Multicentre study analyzes genomic changes in pneumococci post-vaccine in children, indicating shifts in strains and resistance.

Key Points

  • This research aims to identify genomic changes in pneumococcal strains and resistance after vaccine introduction in Lima.
  • Retrospective multicentre study using whole-genome sequencing data
  • Analysis of 262 pneumococcal isolates from three passive surveillance studies
  • Identification of clonal complexes with eBURST and visualization via PHYLOViZ
  • Vaccine serotypes decreased while non-vaccine serotypes like 19A increased after PCV introduction
  • Overall penicillin non-susceptibility rose from 21.8% to 28.6%
  • Resistance markers for macrolides increased significantly post-PCV13

Cite This Study

Gonzales et al. (2026) studied this question.

synapsesocial.com/papers/698435fff1d9ada3c1fb57eahttps://doi.org/10.1099/mgen.0.001621
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