Viburnum cylindricum Buch. -Ham. ex D. Don is abundant in bioactive secondary metabolites with promising functions such as anti-inflammation and anti-diabetes. In this work, the polyphenolic extract of V. cylindricum leaves (VCLP) exhibited significant inhibition on α-glucosidase and urease activity. Two previously undescribed phenolic glycosides (1, 2) and fourteen known analogues (3-16) were isolated from VCLP, which were determined by spectroscopic analyses and chemical methods. The bioactivity assessment revealed that compounds 3, 4, 8, 14, and 16 could potently inhibit α-glucosidase activity with IC50 values ranging from 20.83 to 28.52 μM compared to acarbose (IC50 = 29.71 μM) (p 3 and 4 showed significant urease inhibition with IC50 values of 10.73 and 7.61 μM, respectively, comparable to thiourea (IC50 = 28.57 μM) (p α-glucosidase and urease.
Chen et al. (Tue,) studied this question.