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Research Paper | Synapse

February 6, 2026Open Access

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Methamphetamine regulates microglial polarization and glycolytic activity to promote Parkinson's disease through the LIPH/LPA/PI3K/AKT signaling axis

YZYanghong Zou CZChunhai ZhangKunming Medical University HBHui BianKunming Medical University

Key Points

The study investigates how methamphetamine influences microglial polarization and glycolytic activity in Parkinson's disease.
Analyzed the effects of methamphetamine on microglial cells
Examined activation of LIPH/LPA/PI3K/AKT signaling pathway
Assessed changes in M1 polarization and glycolytic activity
Methamphetamine increased M1 polarization in microglia
Glycolytic activity in microglia was elevated following methamphetamine exposure
Activation of LIPH/LPA/PI3K/AKT signaling correlated with these changes

Abstract

METH may promote M1 polarization and glycolytic activity in microglia by activating LIPH/LPA/PI3K/AKT signaling, thus promoting the progression of PD.

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Cite This Study

Zou et al. (Sun,) studied this question.

synapsesocial.com/papers/698584b78f7c464f230080f5 https://doi.org/https://doi.org/10.1016/j.intimp.2026.116306