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Meta-analysis identifies IL-8 -251 as a high-risk biomarker and +2767 as protective in prostate cancer, suggesting ethnic-specific risk stratification.
This pioneering meta-analysis identifies the IL-8 -251 polymorphism as a high-risk biomarker and +2767 as a protective variant. By functionally validating that the -251 risk allele promotes PCa progression via IL-8 overexpression, the present study establishes IL-8 genotyping as a potential tool for ethnic-specific risk stratification and prognostic prediction, with broad implications for precision oncology.
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Zhang et al. (2026) studied this question.
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