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This research aims to examine the relationship between plaque composition and disease progression in patients with non-obstructive coronary artery disease.

February 6, 2026Journal of cardiovascular computed tomography4 citationsOpen Access

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Disease progression and plaque composition in patients with non-obstructive coronary artery disease (THRONE): A coronary computed tomography angiography follow-up study

KMKarim D. MahmoudErasmus MC SSSimran P. SharmaErasmus MC Cancer Institute RBRicardo P.J. BuddeCardiac Imaging

Key Points

This research aims to examine the relationship between plaque composition and disease progression in patients with non-obstructive coronary artery disease.
Follow-up study design using coronary computed tomography angiography
Selected cohort of patients with non-obstructive coronary artery disease
Assessment of plaque composition
Measurement of fractional flow reserve computed tomography (FFRct) at two-year follow-up
Higher plaque burden was linked with an FFRct ≤0.80
Presence of high-risk plaque composition was observed
Significant rates of coronary revascularization in patients with intermediate lesions

Abstract

Rates of coronary revascularization are substantial in patients with medically managed intermediate lesions. In this selected cohort, an FFRct ≤0.80 at two-year follow-up was associated with higher plaque burden and presence of high-risk plaque composition.

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Disease progression and plaque composition in patients with non-obstructive coronary artery disease (THRONE): A coronary computed tomography angiography follow-up study

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Abstract

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