Multi-omics analysis reveals distinct molecular features and a gene signature for prognosis in hepatocellular carcinoma, suggesting new personalized treatment strategies.
Our study characterizes the molecular and clinical distinctions between ecDNA-negative and ecDNA-positive HCC and establishes a clinically applicable gene signature for patient prognosis. These findings advance our understanding of ecDNA-driven tumor heterogeneity and provide potential strategies for personalized HCC management.
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Huang et al. (2026) studied this question.
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