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February 6, 2026Open Access

Effects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients

MAMehrsadat Alavi RHRaziyeh HojjatFasa University of Medical Sciences ATAli TaghinezhadFasa University of Medical Sciences

Key Points

The central aim is to evaluate the impact of high-dose radioactive iodine therapy on hormonal profiles and sperm quality in thyroidectomy patients.
Evaluated male thyroidectomy patients receiving 150 mCi of radioactive iodine therapy
Monitored hormonal profiles and sperm quality measures
Long-term follow-up proposed to assess the effects on reproductive health
No impairment in fertility was observed among the patients
Results suggest stable hormonal profiles post-treatment
Indications for further research on sperm dna fragmentation and amh levels

Abstract

Male patients who received 150 mCi of radioactive iodine showed no impairment in fertility. Long-term follow-up studies with larger sample sizes are crucial to investigate the physiological roles of gonadal hormones, sperm DNA fragmentation, and AMH in the testes after RIT.

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