High-Resolution OCT Profiling of Bruch's Membrane in Extensive Macular Atrophy With Pseudodrusen-Like Appearance and Geographic Atrophy

Alberto Quarta; Mai Alhelaly; Francesco Romano; Ceren Soylu; Raiyna Rattu; Claudia Nardi; Andrea Trinco; Federico Corvi; Rouzbeh Abbasgholizadeh; Shinichiro Chujo; Giulia Corradetti; Alessandro Feo; Muneeswar G. Nittala; Jingyi Huang; Giovanni Staurenghi; Srinivas R. Sadda

doi:10.1167/iovs.67.2.12

February 3, 2026Investigative Ophthalmology & Visual ScienceOpen Access

High-Resolution OCT Profiling of Bruch's Membrane in Extensive Macular Atrophy With Pseudodrusen-Like Appearance and Geographic Atrophy

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Key Points

The aim is to investigate the changes in Bruch's membrane associated with extensive macular atrophy and their implications for atrophy progression.
High-resolution optical coherence tomography (OCT) used for profiling Bruch's membrane
Examined areas with extensive macular atrophy and pseudodrusen-like appearance
Identified pathways of Bruch's membrane failure through detailed imaging analysis
BMBs were more frequently found in areas with widespread BLamD debris
Geographic atrophy revealed focal, calcified defects related to HPS
Highlighted the distinct pathways of BM failure between EMAP and GA.

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Implication

This analysis demonstrates pathways of Bruch's membrane failure in macular atrophy, indicating differing mechanisms in atrophy progression.

Abstract

BMBs associated with EMAP are more likely to be found in widespread BLamD debris areas, while GA shows focal, calcified defects associated with HPS. These findings suggest distinct pathways of BM failure, diffuse in EMAP and focal and mechanical in GA. The clinical implications of these differences and their impact on atrophy progression warrant further study.

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Quarta et al. (2026) studied this question.

synapsesocial.com/papers/698584f98f7c464f23008413 https://doi.org/10.1167/iovs.67.2.12

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High-Resolution OCT Profiling of Bruch's Membrane in Extensive Macular Atrophy With Pseudodrusen-Like Appearance and Geographic Atrophy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

High-Resolution OCT Profiling of Bruch's Membrane in Extensive Macular Atrophy With Pseudodrusen-Like Appearance and Geographic Atrophy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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