3-(Pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives: synthesis, Mycobacterium tuberculosis CYP121A1 enzyme inhibition and antimycobacterial activity vs drug-sensitive and drug-resistant strains

Key Points

• The research aims to synthesize compounds that inhibit the CYP121A1 enzyme in Mycobacterium tuberculosis and evaluate their antimycobacterial activity.
• Synthesis of 3-(pyridine-3-ylmethylene)chroman-4-one and tetralone derivatives.
• Testing of these derivatives for CYP121A1 enzyme inhibition.
• Evaluation of the compounds’ efficacy against drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis.
• Identified significant inhibition of CYP121A1 by several synthesized derivatives.
• Demonstrated effective antimycobacterial activity against both drug-sensitive and drug-resistant strains.