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Demonstrates a new method to stabilize biologics in high heat, suggesting a way to improve their delivery.
This paper details a stimuli-responsive 'Vimana' architecture designed to stabilize fragile biologics through nanoconfinement-induced geometric frustration. By integrating a phyllosilicate thermal mantle with a piezoelectric cyclosilicate resonator, we demonstrate a solid-state vehicle capable of maintaining amorphous stability under high-heat stress (>50°C) and achieving magneto-acoustic triggered release. This mineral-based platform provides a hierarchical mechanical intervention to rescue 'Lazarus' compounds—therapeutics with high biological efficacy but prohibitive pharmacokinetic flaws.
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Ross Tunnicliffe (2026) studied this question.
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