Cross-sectional analysis identifies progressive microvascular changes in glaucoma severity using OCT-A.
Key Points
The study aims to quantitatively analyze microvascular characteristics in the macula of healthy eyes versus those with open-angle glaucoma.
Conducted a cross-sectional study with 144 eyes, including 109 with open-angle glaucoma and 35 healthy eyes.
Categorized glaucoma severity into early, moderate, and severe stages using Hodapp-Anderson-Parrish classification.
Performed visual field tests, optical coherence tomography, and optical coherence tomography angiography examinations.
Macular vessel density significantly reduced across different glaucoma stages, with foveal density decreasing from 23 ± 1.9% in healthy eyes to 13.9 ± 1.8% in severe glaucoma.
Foveal and parafoveal vessel densities notably decreased even in early-stage glaucoma.
OCT parameters, including total ganglion cell complex thickness, diminished progressively with glaucoma severity.