Key result
Abdominal obesity in hypertensive patients is linked to ~2-fold higher IL-17A levels.
Observational (n=129)
Pro-inflammatory cytokine IL-17A is significantly elevated in patients with arterial hypertension, particularly when combined with abdominal obesity, and correlates with insulin resistance and hsCRP.
Background/Introduction When arterial hypertension (AH) is combined with abdominal obesity (AO), hypertension becomes more severe, primarily due to the development of insulin resistance (IR) and subclinical inflammation. One of the powerful pro-inflammatory factors is interleukin-17A (IL-17A). However, its role in the pathogenesis of AH in AO remains insufficiently understood. Purpose To study the features of changes in blood IL-17A levels in patients with AH and AO in comparison with patients with AH and normal body weight (NBW). Methods The following patients were examined: 54 patients with AH of 2-3 degrees and AO of class I-II (30 men and 24 women) aged 39-59 years (main group); 50 patients with grade 2-3 AH with LBW (32 men and 28 women) aged 37-59 years (comparison group) and 25 practically healthy individuals (12 men and 10 women) aged 19-47 years (control group). The examination included standard general clinical methods, as well as determination of blood levels of IL-17A, insulin and high-sensitivity C-reactive protein (hsCRP) using the enzyme immunoassay method. IR was determined by HOMA-IR. Results Levels of IL-17A in the blood of patients with AH, both with AO ((14.38 [6.33;23.79]) pg/ml) and with NBW ((7.03 [4.55;11.26]) pg/ml), were significantly higher (p<0.05) than in practically healthy individuals ((3.20 [0.94;4.65]) pg/ml). The highest levels of IL-17A were in AH and AO - significantly higher (p<0.05) than in AH and NBW. Moreover, if in patients with AH and NBW the levels of IL-17A most significantly correlated with the levels of hsCRP (p = 0.034), systolic blood pressure (SBP) (p = 0.042) and left ventricular mass index (LVMI) (p = 0.041), then in patients with AH and AO - with IR (p = 0.020), body mass index (BMI) (p=0.023) and with hsCRP (p=0.024). Conclusion(s) In patients with AH, a significant increase in blood levels of the pro-inflammatory cytokine IL-17A was found, which were highest when hypertension was combined with AO and significantly correlated in these patients, primarily with IR, severity of obesity and hsCRP.
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Koval et al. (2025) conducted an observational in Arterial hypertension and abdominal obesity (n=129). Arterial hypertension with abdominal obesity vs. Arterial hypertension with normal body weight and healthy controls was evaluated on Blood levels of IL-17A (pg/ml) (p=<0.05). Arterial hypertension combined with abdominal obesity was associated with significantly higher blood levels of IL-17A (14.38 pg/ml) compared to hypertension with normal body weight (7.03 pg/ml) and healthy controls (3.20 pg/ml) (p<0.05).
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