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February 6, 2026Chemical Communications2 citations

Targeted degradation of BRD4 by PROTACs: advances in cancer therapy

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YHYanyun HongXLXiang LiuYLYanfang Li

Key Points

  • The central aim is to explore optimization strategies for BRD4-targeting PROTACs in cancer therapy.
  • Illustration of optimization strategies for BRD4-targeting PROTACs.
  • Design of a ternary complex for effective targeting.
  • Development of controllable activation systems for PROTACs.
  • Implementation of targeted delivery approaches.
  • Enhanced understanding of multidimensional strategies for PROTACs.
  • Potential improvements in cancer treatment efficiency.

Abstract

This schematic illustrates the multidimensional optimization strategies for BRD4-targeting PROTACs, encompassing the rational design of the ternary complex, diverse controllable activation systems, and targeted delivery approaches.

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Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/6985859b8f7c464f23009208https://doi.org/10.1039/d5cc05563f
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