Conditioned media from left ventricular mesenchymal stromal cells of patients with ischemic heart disease or heart failure induced a 29% increase in lung cancer cell proliferation (p<0.001).
Do cardiac mesenchymal stromal cells from ischemic or failing hearts promote lung cancer cell proliferation?
Cardiac mesenchymal stromal cells from ischemic or failing human hearts undergo chromatin remodeling to secrete factors that significantly increase lung cancer cell proliferation in vitro.
Effect estimate: 29% increase
p-value: p=<0.001
Abstract Background 0.001, Figure 1C). Conclusions For the first time, we show that human ischemic or failing hearts reprogram cardiac mesenchymal stromal cells to secrete pro-tumorigenic factors and stimulate proliferation of lung cancer cells. Understanding this interaction could foster the development of preventive treatment for heart disease and cancer.
Caller et al. (Sat,) conducted a other in Ischemic heart disease and heart failure (n=30). Conditioned media from IHD/HF LV-MSCs vs. Conditioned media from rAT-MSCs or control was evaluated on Lung cancer cell proliferation (29% increase, p=<0.001). Conditioned media from left ventricular mesenchymal stromal cells of patients with ischemic heart disease or heart failure induced a 29% increase in lung cancer cell proliferation (p<0.001).