Abstract Backgrounds Serum ferritin levels are widely known as a marker of inflammation. Serum ferritin levels are associated with adverse outcomes in the general population and various pathological conditions. Both low and high ferritin values were associated with all-cause mortality in some general population studies. However, there are no information available on wound healing in chronic limb-threatening ischemia (CLTI) patients. Methods and Results To investigate whether serum ferritin levels could predict wound healing in CLTI patients after endovascular Therapy (EVT), we retrospectively analyzed total of 128 limbs in 118 patients with CLTI who underwent EVT between July 2022 and July 2024. Study patients were divided into 2 groups according to serum ferritin levels, the high ferritin (250ng/ml, n=52) and the low ferritin groups (≦250, n=75). There were no significant differences in gender, hypertension, hemoglobin, chronic kidney disease or serum iron between the high and low ferritin groups. The primary outcome measure was 6-month wound healing after EVT. Fifty-one patients attained complete wound healing without major amputation at 6months. At Cox multivariable hazard analysis, low ferritin was significantly associated with wound healing independently of BNP after the adjustment with age and C-reactive protein. Kaplan-Meier analysis revealed that the low ferritin group patients had significantly higher wound healing rate than the high ferritin group (adjusted hazard ratio:2.931.48-6.31, p=0.001).Kaplan-Meier analysis for wound healing
Nakamura et al. (Sat,) studied this question.