Iron-catalyzed cascade one-pot reaction between azlactones and O -acetyl oximes to afford 6 H -pyrrolo[3,2- d ]oxazole and pyrrol-2-one nucleus

Parth P. Patel; Rajnikant N. Ghoghari; Kishor H. Chikhalia

doi:10.1039/d5nj04122h

January 1, 2026New Journal of Chemistry

Iron-catalyzed cascade one-pot reaction between azlactones and O -acetyl oximes to afford 6 H -pyrrolo[3,2- d ]oxazole and pyrrol-2-one nucleus

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Key Points

This research aims to develop a unified and controlled reaction for synthesizing complex organic compounds.
Utilized iron as a catalyst for the reaction.
Performed a one-pot reaction combining azlactones and O-acetyl oximes.
Monitored the reaction conditions for optimal outcomes.
Successfully synthesized 6H-pyrrolo[3,2-d]oxazole and pyrrol-2-one.
Demonstrated a unified pathway for complex organic synthesis.

Implication

Controlled cyclization produces 6H-pyrrolo[3,2-d]oxazole and pyrrol-2-one nuclei from azlactones and O-acetyl oximes, indicating a new synthesis method.

Abstract

A unified and controlled cyclization reaction between azlactone and O -acetyl oxime is accomplished.

Discussion

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Cite This Study

Patel et al. (2026) studied this question.

synapsesocial.com/papers/698586498f7c464f2300a458 https://doi.org/10.1039/d5nj04122h

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Iron-catalyzed cascade one-pot reaction between azlactones and O -acetyl oximes to afford 6 H -pyrrolo[3,2- d ]oxazole and pyrrol-2-one nucleus

Key Points

Implication

Abstract

Discussion

Cite This Study

Iron-catalyzed cascade one-pot reaction between azlactones and O -acetyl oximes to afford 6 H -pyrrolo[3,2- d ]oxazole and pyrrol-2-one nucleus

Key Points

Implication

Abstract

Discussion

Cite This Study

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