PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 8, 2026Journal of Interventional Cardiac Electrophysiology2 citationsOpen Access

Thermal preconditioning of targeted tissue enhances pulsed field ablation lesions

DCDaniel Campos-VillarrealMCMaxwell CollLMLogan McClennen

Key Points

  • This research aims to evaluate how thermal preconditioning affects lesion formation in pulsed field ablation.
  • In vitro model utilized to observe effects of tissue temperature on lesion characteristics.
  • Tissues subjected to varying temperatures before pulsed field ablation to assess lesions.
  • Lesion diameter and depth measured post-ablation.
  • Thermal preconditioning significantly increased lesion diameter and depth.
  • Higher initial tissue temperatures reduced the electroporation threshold.
  • These alterations in lesion characteristics imply enhanced efficacy of pulsed field ablation.

Abstract

In this in vitro model, thermal preconditioning significantly alters PFA lesion formation. Increasing the tissue temperature prior to ablation markedly increases lesion diameter and depth, possibly by lowering the electroporation threshold. These findings suggest that tissue temperature is a tunable factor influencing PFA efficacy.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Campos-Villarreal et al. (2026) studied this question.

synapsesocial.com/papers/6988270a0fc35cd7a8845dc3https://doi.org/10.1007/s10840-026-02247-4
Ask AI
Helpful
Bookmark
Share
View Full Paper