Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

Ninon Mounier; Bethany Voller; Jane A. H. Masoli; João Delgado; F Dudbridge; Luke Pilling; T Frayling; Jack Bowden; Jane A. H. Masoli; Olivia Murrin; Linus Tata; Carlos Gallego-Moll; Albert Roso‐Llorach; Lucía A. Carrasco-Ribelles; C Fox; Louise M. Allan; Ruby M Woodward; Xiaoran Liang; Jose M. Valderas; Sara Khalid; Sally E. Lamb; Mary E. Mancini; Leon Farmer; Kate Boddy; David Melzer; Concepción Violán

doi:10.1038/s43856-025-01347-y

Key Points

The research aims to quantify how obesity contributes to the occurrence of multiple long-term conditions through genetic analysis.
Implemented a genetics-centered approach to assess the role of obesity in multi-morbidity.
Utilized a method for calculating full and partial genetic correlations.
Published the method as an R package named partialLDSC.
Obesity was identified as a significant shared risk factor for various long-term conditions.
Quantitative measures of genetic contribution to multi-morbidity were established.

Implication

Genetics-centered approach quantifies obesity's role in multi-morbidity, indicating its health impact.

Abstract

Our genetics-centred approach quantifies the contribution of obesity to multi-morbidity. Our method for calculating full and partial genetic correlations is published as an R package {partialLDSC}.

Discussion

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Cite This Study

Mounier et al. (2026) studied this question.

synapsesocial.com/papers/6988270a0fc35cd7a8845e41 https://doi.org/10.1038/s43856-025-01347-y

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Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

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