The research aims to quantify how obesity contributes to the occurrence of multiple long-term conditions through genetic analysis.
Implemented a genetics-centered approach to assess the role of obesity in multi-morbidity.
Utilized a method for calculating full and partial genetic correlations.
Published the method as an R package named partialLDSC.
Obesity was identified as a significant shared risk factor for various long-term conditions.
Quantitative measures of genetic contribution to multi-morbidity were established.
Abstract
Our genetics-centred approach quantifies the contribution of obesity to multi-morbidity. Our method for calculating full and partial genetic correlations is published as an R package partialLDSC.