Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Nan Yao; Yajing Chen; Guanwei Shen; Y. Zhang; Shuting Yu; Meng Li; Chuan Hui Nie

doi:10.1080/02713683.2026.2621957

February 4, 2026Current Eye Research

Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

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Key Points

This research aims to investigate how Pannexin-1 inhibition affects neovascularization in a model of oxygen-induced retinopathy.
Used PBC to inhibit Panx1 in vitro.
Assessed effects on HIF-1α/VEGF signaling pathway.
Measured hypoxia-induced endothelial cell proliferation.
HIF-1α/VEGF signaling was significantly suppressed with Panx1 inhibition.
Endothelial cell proliferation was reduced under hypoxic conditions.

Implication

Inhibition of HIF-1α/VEGF signaling reduces endothelial cell growth in oxygen-induced retinopathy, suggesting a new preventive approach.

Abstract

Panx1 inhibition (via PBC) suppresses the HIF-1α/VEGF signaling pathway and reduces hypoxia-induced endothelial cell proliferation, providing a novel preventive strategy for ROP.

Discussion

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6988270a0fc35cd7a8845ed3 https://doi.org/10.1080/02713683.2026.2621957

View at Publisher

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Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Key Points

Implication

Abstract

Discussion

Cite This Study

Pannexin-1 Inhibits Pathologic Neovascularization in Oxygen-Induced Retinopathy by Targeting the HIF-1α/VEGF Pathway in Vitro

Key Points

Implication

Abstract

Discussion

Cite This Study

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