Time-Dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal Cells

Sudeep Mehrotra; H Jeanneret; Kristin Perkumas; Renee Liu; Jyoti Lama; Katie Huynh; Ananya Mukundan; Hilary Scott; Atitaya Apivatthakakul; Janey L. Wiggs; Lucia Sobrin; W. Daniel Stamer; Ayellet V. Segrè

doi:10.1167/iovs.67.2.13

February 4, 2026Investigative Ophthalmology & Visual ScienceOpen Access

Time-Dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal Cells

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Key Points

The aim is to explore how glucocorticoids affect gene expression in eye cells, contributing to ocular hypertension.
Analyzed transcriptomic changes in trabecular meshwork and Schlemm's canal cells over time.
Identified candidate genes related to glucocorticoid exposure.
Explored potential pathways involved in ocular hypertension.
Candidate genes linked to glucocorticoid-induced changes were identified.
Pathways related to ocular hypertension were proposed for further genetic studies.

Implication

This research identifies genes linked to glucocorticoid-induced ocular hypertension, suggesting new avenues for genetic studies.

Abstract

This study identified candidate genes and pathways for glucocorticoid-induced ocular hypertension which can be further explored in human genetic analyses.

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Cite This Study

Mehrotra et al. (2026) studied this question.

synapsesocial.com/papers/698827570fc35cd7a8845f41 https://doi.org/10.1167/iovs.67.2.13

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Time-Dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Time-Dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm's Canal Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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