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February 8, 2026NeurotherapeuticsOpen Access

Non-neuronal targets for migraine therapy

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Authors

OGOtilia GligaAFAlbert Feliu-SolerMSMarkus Schürks

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Overview

Review highlights non-neuronal targets for migraine therapy, suggesting new treatment approaches for better outcomes.

Key Points

  • This review aims to explore the role of non-neuronal cells in the pathophysiology of migraine and their potential as therapeutic targets.
  • Reviewed existing literature on migraine pathophysiology focusing on non-neuronal cells
  • Examined the roles of astrocytes, microglia, and satellite glial cells in migraine mechanisms
  • Discussed potential therapeutic interventions involving CGRP and PACAP
  • Non-neuronal cells like astrocytes and microglia are implicated in migraine mechanisms
  • CGRP and PACAP therapies target these non-neuronal cells
  • Macrophages may enhance anti-inflammatory responses in migraine treatment
  • Mast cells show promise as targets due to their receptor expression and ongoing clinical studies

Cite This Study

Gliga et al. (2026) studied this question.

synapsesocial.com/papers/698827570fc35cd7a8846006https://doi.org/10.1016/j.neurot.2026.e00845
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