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February 8, 2026European Heart Journal0 citations

Diagnostic Performance of Cardiac Diffusion Tensor Imaging in Subclinical Hypertrophic...

Diagnostic performance of cardiac diffusion tensor imaging in subclinical hypertrophic cardiomyopathy: a comparison with strain analysis

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Why the study?

Does cardiac diffusion tensor imaging (cDTI) improve diagnostic performance compared to 3D-FT strain in identifying subclinical hypertrophic cardiomyopathy?

Population

90 subjects, including 67 patients with subclinical hypertrophic cardiomyopathy and 23 healthy volunteers…

Comparison

Cardiac diffusion tensor imaging using 3T… vs 3D feature-tracking (FT) strain analysis

Design

Cross-sectional

Key result

Cardiac diffusion tensor imaging (cDTI) showed superior diagnostic performance (AUC up to 0.828) versus 3D-FT strain (AUC ~0.55) in identifying subclinical HCM.

Authors

MAM E H A K AsadGJG JoyMLMay T Lwin

Discussion

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Overview

cDTI may outperform strain for subclinical HCM detection; hypothesis-generating and should not yet change practice.

Key Points

  • The study aims to evaluate the effectiveness of cardiac diffusion tensor imaging compared to myocardial strain analysis in identifying subclinical hypertrophic cardiomyopathy.
  • Conducted a multi-centre analysis with 90 participants, including healthy volunteers and HCM patients.
  • Performed cardiac magnetic resonance imaging using a 3T scanner, including cDTI and strain analysis.
  • Calculated cDTI biomarkers: mean diffusivity, fractional anisotropy, and secondary eigenvector angle.
  • Employed statistical analysis including ROC curves to assess diagnostic performance.
  • Significant differences in cDTI biomarkers between HCM patients and healthy volunteers.
  • Strain measurements showed no significant differences between the two groups.
  • cDTI biomarkers demonstrated better diagnostic performance with AUC values for MD, FA, and E2A.

Structured PICO

Does cardiac diffusion tensor imaging (cDTI) improve diagnostic performance compared to 3D-FT strain in identifying subclinical hypertrophic cardiomyopathy?

P
Population
90 subjects, including 67 patients with subclinical hypertrophic cardiomyopathy (genotype positive phenotype negative, G+LVH-) and 23 healthy volunteers. HCM patients had a mean age of 33±11 years and 40 were female.
I
Intervention
Cardiac diffusion tensor imaging (cDTI) using 3T cardiac magnetic resonance
C
Comparator
3D feature-tracking (FT) strain analysis
O
Outcome
Diagnostic performance (Area Under the Curve) in identifying subclinical hypertrophic cardiomyopathysurrogate

Cardiac diffusion tensor imaging is more sensitive than 3D feature-tracking strain for detecting early microstructural changes in subclinical hypertrophic cardiomyopathy.

Cite This Study

Asad et al. (2025) studied this question. Cardiac diffusion tensor imaging (cDTI) showed superior diagnostic performance (AUC up to 0.828) versus 3D-FT strain (AUC ~0.55) in identifying subclinical HCM.

synapsesocial.com/papers/6988278b0fc35cd7a88465achttps://doi.org/10.1093/eurheartj/ehaf784.239
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