Findings reveal genetic variants influence colorectal cancer risk related to physical activity, suggesting complex interactions.
In summary, we identified two genetic variants that modified the association between physical activity and CRC risk. One of them, related to GREM1 and SCG5, suggests that the bone morphogenetic protein (BMP)-related, inflammatory, and/or insulin signaling pathways may be involved in the protective association between physical activity and colorectal carcinogenesis.
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Peoples et al. (2026) studied this question.
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