What question did this study set out to answer?

This analysis aims to explore the relationship between epigenetic age and cardiometabolic diseases in adults in Guatemala.

February 8, 2026Journal of Health Population and Nutrition0 citationsOpen Access

Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis

MCMelissa ChapnickEmory University EYElaine A. YuUniversity of California, San Francisco ASA. David SmithSemmelweis University

Key Points

This analysis aims to explore the relationship between epigenetic age and cardiometabolic diseases in adults in Guatemala.
Conducted a cross-sectional analysis
Measured epigenetic age using multiple epigenetic clocks
Assessed the presence of multiple cardiometabolic conditions
Found consistent associations between accelerated DunedinPACE and various cardiometabolic conditions
Observed links between epigenetic age acceleration and diabetes
Highlighted the need for further longitudinal studies to understand causality.

Abstract

We observed consistent associations of accelerated DunedinPACE with multiple cardiometabolic conditions. All epigenetic clocks showed associations of epigenetic age acceleration with diabetes. These findings emphasize the need for longitudinal analyses to determine the direction and causality of these relationships.

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