Cross-sectional analysis finds epigenetic age acceleration linked to cardiometabolic conditions, suggesting further study is needed.
We observed consistent associations of accelerated DunedinPACE with multiple cardiometabolic conditions. All epigenetic clocks showed associations of epigenetic age acceleration with diabetes. These findings emphasize the need for longitudinal analyses to determine the direction and causality of these relationships.
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Chapnick et al. (2026) studied this question.
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