The effect of cynaropicrin, a sesquiterpene lactone, on the migratory properties of triple-negative breast cancer cells and the underlying mechanisms.

Mauricio Amaral; Hamad Ali Hamad; Soumya V Menon; Mandeep Kaur; Gv Sivaprasad; Wesam R. Kadhum; Subasini Uthirapathy; Mohammed A. Ullah; Mohammed Abed Jawad; Yasser Fakri Mustafa

doi:10.22038/ajp.2025.25894

January 1, 2026

The effect of cynaropicrin, a sesquiterpene lactone, on the migratory properties of triple-negative breast cancer cells and the underlying mechanisms.

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate the effects of cynaropicrin on the migratory behavior of triple-negative breast cancer cells and elucidate the underlying mechanisms.
Conducted experiments on triple-negative breast cancer cell lines.
Analyzed the effect of cynaropicrin on epithelial-mesenchymal transition (EMT).
Measured levels of pro-angiogenic factors such as VEGFA.
Cynaropicrin was found to inhibit migration of triple-negative breast cancer cells.
Cynaropicrin reduced the expression of EMT markers.
Decreased levels of VEGFA were observed, supporting anti-angiogenic properties.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Findings demonstrate cynaropicrin inhibits migration in triple-negative breast cancer, suggesting therapeutic potential.

Abstract

The present findings indicated the anti-metastatic capacity of cynaropicrin against TNBC by a mechanism that implicated the inhibition of the EMT and pro-angiogenic factor VEGFA. These outcomes suggest cynaropicrin as an anti-metastatic and anti-angiogenic sesquiterpene lactone against TNBC.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Amaral et al. (2026) studied this question.

synapsesocial.com/papers/698827c90fc35cd7a8846c4b https://doi.org/10.22038/ajp.2025.25894

View Full Paper

Ask AI

Bookmark

Share

The effect of cynaropicrin, a sesquiterpene lactone, on the migratory properties of triple-negative breast cancer cells and the underlying mechanisms.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The effect of cynaropicrin, a sesquiterpene lactone, on the migratory properties of triple-negative breast cancer cells and the underlying mechanisms.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading