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February 8, 2026AIDS Research and Therapy3 citationsOpen Access

Quercetin ameliorates HIV-1 gp120 protein-induced intestinal barrier dysfunction by inhibiting the activation of the ERK1/2 signaling pathway in a Caco-2 cell model

LZLijiao ZhuJYJiangyu YanQWQinghui Wang

Key Points

  • The aim is to investigate how quercetin impacts intestinal barrier dysfunction linked to HIV-1 gp120 infection.
  • Utilized a Caco-2 cell model to simulate intestinal barrier conditions.
  • Assessed tight junction protein levels after gp120 exposure.
  • Analyzed the activation of the ERK1/2-MLCK signaling pathway in response to treatment with quercetin.
  • Quercetin effectively restored tight junction protein levels altered by gp120.
  • Inhibition of the ERK1/2-MLCK pathway was observed with quercetin treatment.
  • Demonstrated improvement in intestinal barrier integrity compared to untreated cells.

Abstract

Quercetin alleviates gp120-induced intestinal barrier disruption via inhibition of the ERK1/2-MLCK signaling pathway and restoration of tight junction proteins. These findings highlight the therapeutic potential of Quercetin as a natural compound to protect against HIV-related mucosal injury and support its further development for managing HIV-associated comorbidities.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/698828010fc35cd7a8847246https://doi.org/10.1186/s12981-026-00846-9
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