Electroacupuncture improves hypoxic stress and energy metabolism to alleviate vascular cognitive impairment through activation of the HIF-1α/p53/NGB signaling pathway in rats.

Peijia Hu; Fangyuan Xu; Wendong Zhang; Lin Bai; Fan Dai; Yu Ye; Jingji Wang; Hongliang Cheng

doi:10.22038/ijbms.2025.86988.18796

January 1, 2026

Electroacupuncture improves hypoxic stress and energy metabolism to alleviate vascular cognitive impairment through activation of the HIF-1α/p53/NGB signaling pathway in rats.

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Key Points

The research aims to investigate how electroacupuncture affects cognitive dysfunction by alleviating hypoxic stress and enhancing energy metabolism in rats.
Applied electroacupuncture treatment to BCCAO-induced rats
Assessed neurological impairment and cognitive function
Analyzed changes in hypoxic stress markers and energy metabolism
Examined the activation of the HIF-1α/p53/NGB signaling pathway
EA significantly reduced neurological impairment and cognitive dysfunction in treated rats
Improved energy metabolism was observed in the cortex and hippocampus
Activation of the HIF-1α/p53/NGB pathway was confirmed post-treatment

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Implication

EA improves cognitive function in rats with vascular impairment, suggesting a potential therapeutic approach.

Abstract

EA alleviated BCCAO-induced neurological impairment and cognitive dysfunction in rats, possibly by reducing hypoxic stress and enhancing energy metabolism in the cortex and hippocampus, potentially through modulation of the HIF-1α/p53/NGB signaling pathway.

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Hu et al. (2026) studied this question.

synapsesocial.com/papers/698828010fc35cd7a88472ab https://doi.org/10.22038/ijbms.2025.86988.18796

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Electroacupuncture improves hypoxic stress and energy metabolism to alleviate vascular cognitive impairment through activation of the HIF-1α/p53/NGB signaling pathway in rats.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Electroacupuncture improves hypoxic stress and energy metabolism to alleviate vascular cognitive impairment through activation of the HIF-1α/p53/NGB signaling pathway in rats.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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