Physically inactive middle-aged adults have lower LA and LV volumes and LV mass, and though they show worse clinical outcomes, inactivity's link to MACE is not significant after risk adjustment.
Does physical activity level affect left atrial and ventricular volumes and the incidence of major adverse cardiovascular events in middle-aged subjects from the general population?
In middle-aged adults, physical inactivity is associated with smaller cardiac chambers and lower LV mass, but its apparent association with increased MACE is likely mediated by established cardiovascular risk factors.
Absolute Event Rate: 0% vs 0%
Abstract Background The Physical Activity Index (PAI), a self-reported questionnaire-based measure, has been developed to quantify physical activity levels. In this study, we wanted to assess associations between PAI categories and left atrial and ventricular structure and function, as well as the incidence of major adverse cardiovascular events (MACE) in middle-aged subjects from the general population. Methods We performed clinical examination and echocardiography in 3622 subjects from the general population born in the year 1950, during 2012 to 2015. We calculated PAI score based on self-reported frequency, intensity, and duration of physical activity. Participants reporting 1 training per week were classified as physically inactive. Active participants were grouped into low, medium, or high activity levels based on sex-specific distribution of PAI score. MACE was defined as first event of non-fatal myocardial infarction, non-fatal ischemic stroke, non-fatal heart failure, myocardial revascularization (coronary artery bypass grafting or percutaneous revascularization), or cardiovascular death, with follow-up until December 31, 2022. Inactive subjects served as the reference group. All multivariable regression models were adjusted for age, sex, body mass index, current smoking, hypertension, diabetes, history of cardiovascular disease, atrial fibrillation, and C-reactive protein. Results The study population had 51.2% men, and mean age was 63.9 years (range 62.1–65.6 years). Inactive subjects had lower left atrial (LA) volume, lower left ventricular (LV) volume, and lower LV mass in multivariable analyses (Table). During follow-up, inactive subjects experienced more adverse clinical outcomes, but the association between physical inactivity, as classified by PAI category, and MACE was attenuated in multivariable analysis (hazard ratio 1.1, 95% CI 0.9-1.5), p= 0.4). Conclusion Physically inactive subjects from the general population have lower LA and LV volumes and LV mass but worse clinical outcome compared to physically active subjects. Despite these differences, the association between inactivity and MACE was not significant after adjusting for established risk factors, suggesting that these factors may mediate the observed relationship.
Risberg et al. (Sat,) reported a other. Physically inactive middle-aged adults have lower LA and LV volumes and LV mass, and though they show worse clinical outcomes, inactivity's link to MACE is not significant after risk adjustment.
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