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February 8, 2026Contact Dermatitis

Ten Years of Patch Testing to Hydroperoxides of Limonene and Linalool: Prevalence, Patterns and Clinical Insights

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Authors

SBSofia BotvidRSRebekka SøgaardJSJakob Ferløv Baselius Schwensen

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Overview

A retrospective analysis investigates patch test reactions to hydroperoxides in diverse populations, indicating fragrance allergen concerns.

Key Points

  • To analyze patch test reactions to hydroperoxides of limonene and linalool and identify associated reaction patterns.
  • Retrospective analysis of registry data from 6719 patch-tested patients
  • Examination of doubtful reactions categorized as erythematous or infiltrated
  • Assessment of co-reactivity among different fragrance allergens
  • Positive reactions were found in 1.6% for Lim-OOH and 3.1% for Lin-OOH
  • Lim-OOH reactions were less common in men and atopic dermatitis patients
  • Lin-OOH reactions were more prevalent in individuals over 40 years
  • Most reactions peaked on days 3/4 and were generally weakly positive
  • Co-reactivity confirmed allergenicity pertaining to fragrance allergens

Cite This Study

Botvid et al. (2026) studied this question.

synapsesocial.com/papers/698828100fc35cd7a8847395https://doi.org/10.1111/cod.70102
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