What question did this study set out to answer?

To evaluate the effects of Lacticaseibacillus rhamnosus DACN152 on polycystic ovary syndrome in a letrozole-induced murine model.

February 8, 2026Food & Function0 citations

Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

XCXiaoyong ChenSouthwest University XLXiao LiuSouthwest University JWJiajing WangSouthwest University

Key Points

To evaluate the effects of Lacticaseibacillus rhamnosus DACN152 on polycystic ovary syndrome in a letrozole-induced murine model.
Utilized a letrozole-induced PCOS murine model
Administered Lactobacillus strain DACN152
Assessed ovarian histopathology and sex hormone levels
Analyzed microbiota and metabolite profiles
DACN152 improved ovarian histopathology compared to controls
Significant alterations in sex hormone levels were observed
Positive modulation of microbiota and metabolite profiles noted

Abstract

This study investigated the potential role of Lacticaseibacillus rhamnosus DACN152 (DACN152) in ameliorating polycystic ovary syndrome (PCOS). Using a letrozole-induced PCOS murine model, we demonstrated that DACN152 attenuated ovarian histopathological...

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Cite This Study

Chen et al. (Thu,) studied this question.

synapsesocial.com/papers/698828620fc35cd7a8847d35 https://doi.org/https://doi.org/10.1039/d5fo03870g

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