Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

Xiaoyong Chen; Xiao Liu; Jiajing Wang; Amel A. Ibrahim; Zsolt Zalán; Huayi Suo

doi:10.1039/d5fo03870g

January 1, 2026Food & Function

Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

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Key Points

To evaluate the effects of Lacticaseibacillus rhamnosus DACN152 on polycystic ovary syndrome in a letrozole-induced murine model.
Utilized a letrozole-induced PCOS murine model
Administered Lactobacillus strain DACN152
Assessed ovarian histopathology and sex hormone levels
Analyzed microbiota and metabolite profiles
DACN152 improved ovarian histopathology compared to controls
Significant alterations in sex hormone levels were observed
Positive modulation of microbiota and metabolite profiles noted

Implication

Experimental investigation shows DACN152 improves sex hormone balance in a PCOS model, suggesting therapeutic potential.

Abstract

This study investigated the potential role of Lacticaseibacillus rhamnosus DACN152 (DACN152) in ameliorating polycystic ovary syndrome (PCOS). Using a letrozole-induced PCOS murine model, we demonstrated that DACN152 attenuated ovarian histopathological...

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/698828620fc35cd7a8847d35 https://doi.org/10.1039/d5fo03870g

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Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

Key Points

Implication

Abstract

Discussion

Cite This Study

Lacticaseibacillus rhamnosus DACN152 effectively ameliorated letrozole-induced polycystic ovary syndrome: Sex hormones homeostasis, microbiota and metabolite profiles

Key Points

Implication

Abstract

Discussion

Cite This Study

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