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February 8, 2026RSC Advances14 citationsOpen Access

Hydrogel-based drug delivery systems for enhanced tumor therapy

STShijia TianSYShuxiang YangYLYue Liu

Key Points

  • This review aims to explore how hydrogel-based platforms can improve localized cancer therapy and counter drug resistance.
  • Review of existing literature on hydrogel drug delivery systems
  • Analysis of how these systems affect tumor microenvironment
  • Discussion of multiple treatment modalities utilizing hydrogels
  • Hydrogel systems provide spatiotemporal control for drug release
  • Enhanced therapeutic efficacy observed with reduced systemic toxicity
  • Modulation of tumor microenvironment aids in overcoming drug resistance

Abstract

This review highlights hydrogel-based platforms for spatiotemporally controlled, localized cancer therapy, overcoming drug resistance and modulating the tumor microenvironment to enhance efficacy and reduce toxicity for multiple treatment modalities.

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Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/698828620fc35cd7a8847dd0https://doi.org/10.1039/d5ra08269b
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