To evaluate the immunosuppressant activity and morphological changes in Leishmania amazonensis when treated with extracts from Lonchocarpus cultratus seeds.
In vitro testing of L. amazonensis with L. cultratus extracts
Assessment of leishmanicidal effects
Cytotoxicity evaluation on macrophages
Observation of morphological changes
L. cultratus extracts demonstrated leishmanicidal effects on L. amazonensis
Low cytotoxicity observed in macrophages
Immunosuppressive activity confirmed in vitro
Abstract
The results revealed that the activities of the L. cultratus extracts included leishmanicidal effects, low cytotoxicity to macrophages, and immunosuppression in vitro.