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February 8, 2026European Heart Journal0 citations

Predictors of Major Adverse Cardiovascular Events in Wild-Type Transthyretin Amyloid Cardiomyopathy

Predictors of major adverse cardiovascular events in patients with wild-type transthyretin amyloid cardiomyopathy: insights from a regional hospital experience

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Population

45 patients diagnosed with wild-type transthyretin amyloid cardiomyopathy, mean age 80±6 years, 91% male…

Design

Cohort

Follow-up

18 months

Key result

In ATTR-CA patients, atrial fibrillation (OR 24.83) and chronic kidney disease (OR 7.55) independently predicted 18-month MACE, mainly heart failure hospitalizations.

Authors

AMAna Rita MartinsJPJ R PereiraMAM Amado

Discussion

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Overview

AF and CKD may flag higher MACE risk in ATTR-CA; hypothesis-generating in small retrospective cohort, needs prospective validation.

Key Points

  • The study aims to identify predictors of major adverse cardiovascular events (MACE) in patients diagnosed with wild-type transthyretin cardiac amyloidosis.
  • Conducted a retrospective single-center study from 2018 to 2024.
  • Included patients diagnosed with wild-type ATTR-CA based on ESC algorithms.
  • Collected clinical, echocardiographic, electrocardiographic, and analytical data at diagnosis.
  • Out of 45 patients, 20 (44%) experienced MACE within 18 months.
  • Independent predictors of MACE identified were atrial fibrillation and chronic kidney disease.
  • Group with MACE had lower left atrial strain metrics and higher NT-proBNP levels at diagnosis.

Structured PICO

P
Population
45 patients diagnosed with wild-type transthyretin amyloid cardiomyopathy (ATTR-CA), mean age 80±6 years, 91% male, followed at a regional hospital in Portugal.
O
Outcome
Extended MACE (composite of cardiovascular mortality, myocardial infarction, stroke, and HF hospitalizations) assessed 18 months after diagnosiscomposite

In patients with wild-type ATTR-CA, atrial fibrillation, chronic kidney disease, lower left atrial strain, and higher NT-proBNP are significant predictors of 18-month major adverse cardiovascular events.

Cite This Study

Martins et al. (2025) studied this question. In ATTR-CA patients, atrial fibrillation (OR 24.83) and chronic kidney disease (OR 7.55) independently predicted 18-month MACE, mainly heart failure hospitalizations.

synapsesocial.com/papers/698828990fc35cd7a884837chttps://doi.org/10.1093/eurheartj/ehaf784.2736
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