Higher triglyceride glucose index was associated with increased 30-day mortality (HR 1.85; 95% CI 1.46–2.36; P<0.001) in critically ill patients with atherosclerotic cardiovascular disease.
Cohort (n=2,493)
Does a higher triglyceride glucose (TyG) index predict increased mortality and need for early organ support in critically ill patients with ASCVD?
An elevated TyG index is independently associated with increased short- and long-term mortality and earlier need for organ support in critically ill patients with ASCVD.
Effect estimate: 30-day mortality HR 1.85 for highest vs lowest TyG tertile; 90-day HR 1.73; 365-day HR 1.66 (95% CI 30-day: 1.46–2.36; 90-day: 1.39–2.15; 365-day: 1.37–2.03)
p-value: p=<0.001
In critically ill patients with ASCVD, higher TyG index was associated with adverse outcomes, including increased mortality and earlier initiation of organ-supportive interventions. These findings suggest that TyG could serve as a practical biomarker for early risk stratification in this high-risk population, though prospective studies are warranted to confirm its clinical utility.
Wang et al. (2026) conducted a cohort in Critically ill adult patients with atherosclerotic cardiovascular disease admitted to ICU (n=2,493). Stratification by triglyceride glucose (TyG) index tertiles vs. Lowest TyG tertile (T1) was evaluated on All-cause mortality at 30-, 90-, and 365-day following ICU admission (30-day mortality HR 1.85 for highest vs lowest TyG tertile; 90-day HR 1.73; 365-day HR 1.66, 95% CI 30-day: 1.46–2.36; 90-day: 1.39–2.15; 365-day: 1.37–2.03, p=<0.001). Higher triglyceride glucose index was associated with increased 30-day mortality (HR 1.85; 95% CI 1.46–2.36; P<0.001) in critically ill patients with atherosclerotic cardiovascular disease.