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January 1, 2025Open Access

A Comprehensive Meta-Analysis of Exogenous Estrogen, Progesterone, and Testosterone in Animal Models of Ischemic and Hemorrhagic Stroke

Tiffany Kung Angely Claire Cornista Suerte Elmira Khiabani Marin R. Parranto Sara Gannon Arnott Anna C. J. Kalisvaart Shinichi Nakagawa Ana C. Klahr Fred Colbourne

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Key Points

To assess the impact of exogenous estrogen, progesterone, and testosterone on ischemic and hemorrhagic stroke in animal studies.
Conducted a meta-analysis of existing studies on hormone treatment in stroke models.
Included both ischemic and hemorrhagic stroke animal models.
Analyzed the effects of each hormone on stroke outcomes.
Exogenous estrogen showed a significant protective effect against ischemic stroke.
Progesterone appeared to have a moderate impact on reducing hemorrhagic stroke damage.
Testosterone's effects were less consistent across studies.

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Implication

Meta-analysis evaluates the effects of hormones on stroke outcomes in animal models, suggesting therapeutic potential.

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Cite This Study

Kung et al. (2025) studied this question.

synapsesocial.com/papers/698828cb0fc35cd7a8848a0a https://doi.org/10.17605/osf.io/kf7t2

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