Research demonstrates that Bacillus clausii mitigates reproductive dysfunction caused by amoxicillin, suggesting protective effects for male reproductive health.
Key Points
The aim is to investigate how amoxicillin affects male reproductive health and determine the protective role of Bacillus clausii.
Administered amoxicillin to male mice to assess reproductive dysfunction.
Included a control, B. clausii group, AMO-treated group, and AMO plus B. clausii group.
Conducted blood analyses for oxidative stress markers and testosterone levels after treatment.
Evaluated testicular tissue for mTOR expression and histological changes.
Amoxicillin exposure increased oxidative stress and reduced testosterone levels.
Testicular damage and downregulation of mTOR expression were observed with AMO.
B. clausii supplementation reduced oxidative stress markers and improved testosterone levels.
B. clausii alleviated testicular lesions and upregulated mTOR expression.