Demonstrates that Nrf2 de-SUMOylation alleviates myocardial ferroptosis in mice, highlighting a potential therapeutic approach for ischemia-reperfusion injury.
This study highlighted the role of Nrf2 SUMOylation in promoting ferroptosis during MIRI and identified Nrf2 de-SUMOylation as a potential therapeutic target for MIRI.
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Shi et al. (2026) studied this question.
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