Network meta-analysis compares complete revascularization strategies in STEMI patients with multivessel disease, demonstrating angiography-guided efficacy.
Key Points
To compare the effectiveness of angiography-guided and physiology-guided complete revascularization in STEMI patients with multivessel disease.
Conducted a network meta-analysis of 14 randomized controlled trials.
Involved 11,568 patients with ST-segment elevation myocardial infarction and multivessel disease.
Compared outcomes of angio-guided CR, physiology-guided CR, and culprit-only PCI.
Utilized frequentist and Bayesian approaches for efficacy assessment.
Angiography-guided CR significantly reduced major adverse cardiovascular events (MACE) with an odds ratio of 0.44.
Physiology-guided CR also led to a significant reduction in MACE with an odds ratio of 0.64.
No significant differences in outcomes between physiology-guided and angio-guided CR were observed except for a non-significant trend towards lower cardiovascular death in physiology-guided CR.