Outcomes following the discontinuation of biologic therapy in patients with severe asthma

Reoto Takei; Hiroshi Matsumoto; Takashi Iwanaga; Kazuto MATSUNAGA; K Sekiya; Tomoya Harada; Shogo Sakurai; Norihiro Harada; Toshiyuki Koya; Koichi Fukunaga; Takeshi Kaneko; Kazuhisa Asai; Yuko Komase; Yasuhiro Gon; Akihiko Tanaka; H. Sagara; Hironobu Sunadome; Tatsuya Nagano; Yoichi Nakamura; Akio Niimi; Noboru Hattori; Takashi Hajiro; Hajime Fujimoto; Masayuki Hojo; Nobuaki Miyahara; Masafumi Yamaguchi; Kimiko Tsuji; Akiko Sano; Ryuta Haraguchi; Hiroyuki Sano; Masato Muraki; Yuji Tohda

doi:10.1016/j.alit.2025.12.004

Key Points

This research aims to identify risk factors for exacerbations after stopping biologic therapy in severe asthma patients.
Examined baseline eosinophilia and sputum presence during therapy
Analyzed reasons for therapy discontinuation, including poor response and cost
Assessed risk factors in relation to asthma phenotypes and treatment classes
Baseline eosinophilia and persistent sputum are identified as significant risk factors
Exacerbations vary significantly based on asthma phenotype and treatment class
Careful patient selection is highlighted as crucial for managing therapy discontinuation

Implication

Observational study finds exacerbations depend on risk factors in patients with asthma, indicating careful monitoring is needed post-discontinuation.

Abstract

Baseline eosinophilia, persistent sputum during therapy, and discontinuation prompted by poor response or cost may serve as risk factors for post-discontinuation exacerbations; however, risk is phenotype- and class-dependent. Careful patient selection and monitoring are essential when considering the discontinuation of biologic treatment.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Takei et al. (2026) studied this question.

synapsesocial.com/papers/698829520fc35cd7a884991d https://doi.org/10.1016/j.alit.2025.12.004

View Full Paper

Ask AI

Bookmark

Share

Outcomes following the discontinuation of biologic therapy in patients with severe asthma

Key Points

Implication

Abstract

Discussion

Cite This Study

Outcomes following the discontinuation of biologic therapy in patients with severe asthma

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading