TREM2 Variants in Alzheimer's Disease

Rita Guerreiro; Aleksandra Wojtas; José Brás; Minerva M. Carrasquillo; Ekaterina Rogaeva; Elisa Majounie; Carlos Cruchaga; Celeste Sassi; John Kauwe; Steven G. Younkin; Lili‐Naz Hazrati; John Collinge; Jennifer M. Pocock; Tammaryn Lashley; Julie Williams; Jean‐Charles Lambert; Philippe Amouyel; Alison Goate; Rosa Rademakers; Kevin Morgan; John Powell; Peter St George‐Hyslop; Andrew Singleton; John Hardy

doi:10.1056/nejmoa1211851

Key Points

To evaluate the relationship between rare genetic variants in TREM2 and susceptibility to Alzheimer's disease.
Screened for rare heterozygous mutations within the TREM2 gene.
Analyzed the statistical association between TREM2 variant carrier status and Alzheimer's disease risk.
Heterozygous rare variants in TREM2 are associated with a statistically significant increase in the risk of Alzheimer's disease.

Implication

Genetic study demonstrates increased risk of Alzheimer's disease from rare TREM2 variants, highlighting immune pathways in neurodegeneration.

Abstract

Heterozygous rare variants in TREM2 are associated with a significant increase in the risk of Alzheimer's disease. (Funded by Alzheimer's Research UK and others.).

Discussion

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Cite This Study

Guerreiro et al. (2012) studied this question.

synapsesocial.com/papers/69889691e31b71e658b2dfdb https://doi.org/10.1056/nejmoa1211851

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TREM2 Variants in Alzheimer's Disease

Key Points

Implication

Abstract

Discussion

Cite This Study

TREM2 Variants in Alzheimer's Disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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