Maternal adiposity and DNA methylation of TfR2 and HJV genes in early pregnancy: mediating role of inflammation and consequences for iron status

Key Points

• The research aims to investigate the connection between maternal adiposity and epigenetic modifications in iron metabolism genes during early pregnancy.
• Analyzed DNA methylation levels of TfR2 and HJV genes in maternal samples
• Measured inflammation markers related to maternal adiposity
• Evaluated iron status of mothers in early pregnancy
• Increased maternal adiposity correlated with altered DNA methylation patterns in TfR2 and HJV genes
• Inflammation acted as a mediator in the relationship between adiposity and gene methylation
• Changes in gene methylation were associated with variations in maternal iron status