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February 5, 2026The Ocular SurfaceOpen Access

Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye

Kaitlin K. Scholand Laura Schaefer Jianming Shao Zhiyuan Yu Stephen C. Pflugfelder Robert A. Britton Cintia S. de Paiva

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Key Points

The aim is to explore immune pathways linked to dry eye disease (DED) in different diagnoses.
Analyzed transcriptomic data for immune-related differentially expressed genes (DEGs).
Compared findings between Sjögren and non-Sjögren dry eye conditions.
Examined pathways associated with DEGs on the ocular surface.
DED shows similar immune-related DEGs across different diagnoses.
Pathway analysis indicates common underlying immune mechanisms.
Findings support the idea of a unified immune response in dry eye disease.

Implication

Findings reveal similar immune-related pathways in dry eye conditions, suggesting common mechanisms.

Abstract

Our findings demonstrate that DED, regardless of the diagnosis, have similar immune-related DEGs and associated pathways on the ocular surface.

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Cite This Study

Scholand et al. (2026) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e7195 https://doi.org/10.1016/j.jtos.2026.02.001

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