Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye

Key Points

• The aim is to explore immune pathways linked to dry eye disease (DED) in different diagnoses.
• Analyzed transcriptomic data for immune-related differentially expressed genes (DEGs).
• Compared findings between Sjögren and non-Sjögren dry eye conditions.
• Examined pathways associated with DEGs on the ocular surface.
• DED shows similar immune-related DEGs across different diagnoses.
• Pathway analysis indicates common underlying immune mechanisms.
• Findings support the idea of a unified immune response in dry eye disease.