In critically ill patients with depression, initiating SSRIs post-ICU was associated with lower 28-day mortality, while pre-ICU maintenance showed no survival advantage.
Does selective serotonin reuptake inhibitor (SSRI) exposure reduce 28-day in-hospital mortality in critically ill ICU patients with comorbid depression?
In critically ill patients with depression, overall SSRI use does not clearly improve 28-day mortality, though post-ICU initiation may offer a survival signal requiring further prospective study.
Absolute Event Rate: 0% vs 0%
In ICU patients with comorbid depression, overall SSRI exposure was not clearly associated with 28-day mortality after time-aligned analyses. A lower mortality signal was observed for post-ICU initiation, whereas pre-ICU maintenance use showed no survival advantage. These findings are hypothesis-generating and warrant prospective confirmation.
Niu et al. (Sun,) reported a other. In critically ill patients with depression, initiating SSRIs post-ICU was associated with lower 28-day mortality, while pre-ICU maintenance showed no survival advantage.