Natural inhibitors of PTP1B: Caffeic acid, cinnamic acid, and cinnamaldehyde as promising agents against triple-negative breast cancer

Key Points

• The aim is to explore the inhibitory effects of natural compounds on cancer cell viability, particularly in triple-negative breast cancer.
• Evaluated the cell viability of MDA-MB-231 and MCF-7 cell lines after treatment with caffeic acid and cinnamic acid.
• Compared the effects of these compounds on HB2 and MCF-7 cell lines.
• Caffeic acid significantly reduced cell viability in MDA-MB-231 and MCF-7 cells.
• Cinnamic acid showed a notable effect only on MCF-7 cells.
• HB2 cells exhibited reduced viability compared to MCF-7, indicating a stronger effect.