NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway

Shuangshuang Xu; Weiping Wang; Yuhui Sun; Juefei Wu; Wenting Zhang; Gang Ding

doi:10.1016/j.identj.2026.109417

February 5, 2026International Dental JournalOpen Access

NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway

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Key Points

Investigate NLRP12's role in inflammatory response suppression and osteogenic differentiation in periodontal tissue.
Examined the impact of NLRP12 on PDLSCs
Evaluated changes in inflammatory responses
Analyzed osteogenic differentiation pathways
NLRP12 significantly suppressed inflammatory responses
Enhanced osteogenic differentiation of PDLSCs was observed
Downregulation of the nuclear factor kappa-B pathway was confirmed

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Implication

Findings reveal NLRP12 enhances osteogenic differentiation while reducing inflammation in PDLSCs, indicating potential therapeutic targeting.

Abstract

NLRP12 suppressed inflammatory responses while enhancing osteogenic differentiation of PDLSCs via downregulating the activation of the nuclear factor kappa-B pathway, indicating that NLRP12 is a latent target for enhancing PDLSCs-based periodontal tissue regeneration.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e73c6 https://doi.org/10.1016/j.identj.2026.109417

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NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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