PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
February 9, 2026Endocrine Related Cancer

Lipid synthesis seems to drive proliferation in Men1 mouse adrenals and human adrenocortical cell lines

View Full Paper
Ask AI
Bookmark
Share

Authors

AEAdam EdholmSLSu-Chen LiXCXia Chu

Discussion

Loading...

Member takes

Overview

Identifies lipid synthesis pathways driving proliferation in adrenocortical carcinoma, suggesting potential therapeutic targets.

Key Points

  • The study aims to uncover molecular pathways linked to adrenocortical carcinoma and investigate the role of lipid synthesis in tumorigenesis.
  • Utilized proteomic profiling to analyze normal adrenal tissues from Men1 mice and wild-type counterparts.
  • Identified differentially regulated proteins, focusing on ACLY and FASN.
  • Conducted functional assays on H295R adrenocortical cells using ACLY and FASN inhibitors.
  • Performed lipidomic analysis to measure changes in fatty acid levels.
  • Identified 681 proteins, with 52 displaying significant regulation in Men1 adrenal tissues.
  • Inhibition of ACLY and FASN led to reduced cell proliferation in H295R cells in a dose-dependent manner.
  • Significant decreases in palmitic acid and palmitoleic acid were observed in treated cells.
  • High expression of ACLY and FASN correlated with poorer survival outcomes in ACC patients.

Cite This Study

Edholm et al. (2026) studied this question.

synapsesocial.com/papers/69897996f0ec2af6756e7528https://doi.org/10.1530/erc-25-0442
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-depth Genetic and Molecular Characterization of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome2026
  2. 2Updating ACC preclinical models: characterization of two new patient-derived cell lines2026
  3. 3Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and β-Catenin2012 · 170 citations
  4. 4Augmented Global Protein Acetylation Diminishes Cell Growth and Migration of Cholangiocarcinoma Cells2024 · 5 citations
  5. 5Bilateral and recurrent adrenocortical carcinoma in MEN1 – a case report and review of the literature2025