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February 9, 2026Journal of the American Chemical Society

A C 1 -Homologative Trifluoromethylation: Light-Driven Decarboxylative Trifluoroethylation of Carboxylic Acids

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Authors

FBFederico BelnomeAPAntonio PulcinellaSBStefano Bonciolini

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Overview

This approach demonstrates decarboxylative trifluoroethylation of carboxylic acids, suggesting a new method for creating complex organic molecules.

Key Points

  • The research aims to develop a new method for introducing trifluoroethyl groups into organic molecules using visible light.
  • Utilized near visible-light irradiation for the decarboxylative trifluoroethylation of aliphatic carboxylic acids.
  • Generated carbon-centered radicals that react with sulfonyl hydrazones derived from trifluoroacetaldehyde.
  • Analyzed the fragmentation behavior of intermediates using both experimental and computational methods.
  • Established a general and practical method for trifluoroethylation under mild conditions.
  • Demonstrated broad substrate scope, successfully modifying primary, secondary, and tertiary carboxylic acids.
  • Provided mechanistic insights into the reaction through combined experimental and computational studies.

Cite This Study

Belnome et al. (2026) studied this question.

synapsesocial.com/papers/69897996f0ec2af6756e7642https://doi.org/10.1021/jacs.5c21423
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